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Vial - lyophilised powderSubcutaneous (SQ)10 mg
The C-terminal tripeptide of alpha-melanocyte stimulating hormone, retaining the parent molecule’s anti-inflammatory activity without its pigmentary effects.
Delivery and return
Delivery and return
| Standard Delivery (Signed for) | Delivered within 3-5 working days |
| Express Delivery (Standard Parcels) | Delivered within 1-2 working days |
| Extra-Large Parcels (Signed for) | Delivered within 3-5 working days |
| Furniture | Delivery usually takes place within 2 weeks. |
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Shipping Information
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Composition and care
We speak a lot about the importance of gut health—not only for beauty—but also in terms of our overall health, wellbeing and immunity. But before we can fully understand why the gut is so integral to our health, it’s first essential to learn more about the physiology of the gut itself—and how it works.
Research Handling Note
Allow sealed vials to equilibrate to ambient laboratory temperature before opening. This helps minimise the risk of condensation forming within the vial. Keep unopened vials stored at 2-8 C, protected from direct light and moisture. All handling, storage after opening, and laboratory procedures should be carried out according to the receiving laboratory’s established protocols and applicable requirements.
KPV is the three-amino-acid C-terminal fragment of alpha-melanocyte stimulating hormone. Its interest lies in the separation of functions: the parent hormone carries both potent anti-inflammatory activity and melanocortin receptor-mediated pigmentary and cardiovascular effects, whereas the KPV fragment appears to retain the former while largely losing the latter. Preclinical work, principally in murine colitis models, has demonstrated reduction in inflammatory markers and mucosal healing following both systemic and oral administration, with evidence that the peptide is taken up directly by intestinal epithelial cells. There is also an antimicrobial literature. Human clinical trials have not been conducted. PHI supplies KPV for clinician-directed use in an inflammatory or mucosal context.
Active Compound: KPV (Lys-Pro-Val, alpha-MSH 11-13)
Permitted Claim GuidelinesAn anti-inflammatory fragment of alpha-MSH studied in preclinical models of mucosal inflammation. Used under practitioner supervision. Human clinical evidence is not available.
Mechanism of Action
Enters cells directly, including intestinal epithelial cells via the PepT1 transporter, and acts intracellularly to inhibit NF-kB and MAPK inflammatory signalling cascades, reducing production of pro-inflammatory cytokines. Unlike the parent alpha-MSH molecule, this action does not appear to require melanocortin receptor binding, which accounts for the absence of pigmentary effects.
Evidence Grade: D - Preclinical evidence only; no human trials
Clinical Evidence BaseConsistent preclinical data in murine models of colitis showing reduced inflammatory markers and improved mucosal healing. In vitro antimicrobial activity reported against certain bacterial and fungal species. No published human clinical trials.
Literature & ReferencesDalmasso G et al. Gastroenterology, 2008 - PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. | Kannengiesser K et al. Inflamm Bowel Dis, 2008 - melanocortin-derived tripeptide KPV has anti-inflammatory potential. | Cutuli M et al. J Leukoc Biol, 2000 - antimicrobial effects of alpha-MSH peptides.
Safety & Precautions
No significant toxicity signal in animal work, but human safety data are absent and long-term risk is unknown. Immunomodulatory activity warrants caution in patients with autoimmune disease or on immunosuppressive therapy, and in active infection. Not for use in pregnancy or breastfeeding. Injection-site reactions are the most commonly reported effect.
ContraindicationsActive systemic infection; concurrent immunosuppressive therapy without specialist review; pregnancy and breastfeeding; known hypersensitivity.
Storage & HandlingStore lyophilised vial at 2-8 C, protected from light.
Regulatory Status
Not authorised as a medicine in the UK, EU or US. Supplied only through appropriate professional, prescription-led channels.
